IL-1 Polymorphisms, CYP2C19 Genotype and Antibiotic Resistance for Helicobacter pylori Eradication in Thailand
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چکیده
Helicobacter pylori (H. pylori) infection is the main cause of peptic ulcer disease (PUD), mucosa associated lymphoid tissue lymphoma, and gastric cancer (Vilaichone and Mahachai, 2001; Vilaichone et al., 2006). Furthermore, H. pylori eradication potentially reduces the incidence of gastric cancer, especially in high prevalence area of this particular cancer (Ford et al., 2014; Demirel et al., 2013). However, the success of eradication regimens depends on
منابع مشابه
Improved eradication rate of standard triple therapy by adding bismuth and probiotic supplement for Helicobacter pylori treatment in Thailand.
BACKGROUND Helicobacter pylori (H. pylori) remains an important cause of gastric cancer and peptic ulcer disease worldwide. Treatment of H. pylori infection is one of the effective ways to prevent gastric cancer. However, standard triple therapy for H. pylori eradication is no longer effective in many countries, including Thailand. This study was designed to evaluate the efficacy of adding bism...
متن کاملImproved Helicobacter pylori Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement in Thai Patients
Objective: Standard triple therapy for H. pylori eradication is no longer effective in many countries including Thailand. This study was designed to evaluate the efficacy of adding bismuth and probiotic supplement to standard triple therapy for H. pylori eradication in Thai patients. Method: This prospective single-center study was conducted in Thailand. H pylori infected gastritis patients wer...
متن کاملTopic Highlight
The known factors that have contributed to the decline of Helicobacter pylori (H. pylori ) eradication rate include antibiotic resistance, poor compliance, high gastric acidity, high bacterial load, and cytochrome P450 2C19 (CYP2C19) polymorphism. Proton pump inhibitor (PPI) is important in the eradication regimen. The principal enzyme implicated in the metabolism of PPIs is CYP2C19. The effect...
متن کاملEffectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study
Background: Helicobacter pylori (H. pylori) is important cause of peptic ulcer and gastric cancer. Moxifloxacin is effective antibiotic for treatment for H. pylori. However, there were limited studies as first line therapy. Probiotics had been shown to decrease therapy-related side-effect and increase eradication rate. Aim of this study was to evaluate the efficacy of moxifloxacin-dexlansoprazo...
متن کاملOutcomes of a Randomized Controlled Trial Comparing Modified High Dose Omeprazole and Amoxicillin Triple Therapy with Standard Triple Therapy for Helicobacter Pylori Eradication
Background: Helicobacter pylori (H. pylori) infection is related to peptic ulcer diseases and gastric cancer and eradication of H. pylori should be expected to decrease the risk of their development. Factors affecting H. pylori eradication are antibiotic resistance, CYP2C19 genotypes, drug regimen and patient compliance. Increment of omeprazole and amoxicillin dosage in clarithromycin-containin...
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تاریخ انتشار 2016